Free introductory Medicinal Chemistry course from Davidson College

Davidson MOOC course- Medicinal Chemistry
Starts October 13th (late enrollment OK)
Cost: free to audit with both free and for-pay certification options
Prerequisites: general chemistry (binding energies, intermolecular forces), some organic chemistry (line-angle structures and functional groups), knowledge of cell parts and functions, comfort with logarithmic and exponential equations
Time required: 1 hour of video per week, completing all assignments will require approx. 1 hour per day


Topics (appox. 1 wk each):
(1) drug approval process (early drugs, clinical trials, IP factors)
(2) enzymes and receptors (inhibition, Ki, types of ligands, Kd)
(3) pharmacokinetics (Vd, CL, compartment models)
(4) metabolism (phase I and II, genetic factors, prodrugs)
(5) molecular diversity (drug space, combi chem, libraries)
(6) lead discovery (screening, filtering hits)
(7) lead optimization (FG replacements, isosteres, peptidomimetics)
(8) important drug classes (selected examples)